Alzheimer's Disease, a progressive neurodegenerative disorder, affects millions worldwide. Its hallmark features include cognitive decline, memory loss, and impaired daily functioning. Despite decades of research, a definitive cure or universally effective treatment has remained elusive. However, recent developments in intravenous medications offer a glimmer of hope for those affected by this devastating condition. Among the latest breakthroughs is Leqembi, an intravenous drug that holds promise in the battle against this neurological condition. 

Leqembi (also known by its generic name, lecanemab) is a monoclonal antibody that targets beta-amyloid plaques—a critical pathological hallmark of Alzheimer's Disease. These plaques are abnormal accumulations of a protein fragment called beta-amyloid that accumulate in the brains of individuals with Alzheimer's. Administered intravenously, Leqembi specifically binds to beta-amyloid, effectively marking these plaques for removal by the body's immune system. This targeted approach holds immense promise in slowing down or potentially halting the progression of Alzheimer's. Leqembi's journey to approval involved rigorous clinical trials. Initial results have been encouraging, with some studies demonstrating a significant reduction in beta-amyloid plaque burden. Furthermore, early findings suggest potential cognitive benefits for some patients.

While Leqembi represents a significant step forward in Alzheimer's research, it's important to note that it's not a cure-all. Alzheimer's is a complex disease with multiple underlying factors, and a comprehensive treatment approach may involve a combination of therapies. Leqembi is not alone in battling Alzheimer's through intravenous medications. Several other promising candidates are in various stages of development and clinical trials. These include aducanumab, donanemab, and gantenerumab, each targeting beta-amyloid in distinct ways. As with any medical treatment, Leqembi and similar intravenous medications may not suit everyone. Patients and caregivers should discuss openly with healthcare providers to understand the potential benefits, risks, and individualized treatment plans.

The introduction of Leqembi and other intravenous medications marks an exciting chapter in the fight against Alzheimer's Disease. As research and clinical trials progress, the landscape of Alzheimer's treatment is evolving, bringing us closer to more effective therapies and, ultimately, a brighter future for individuals living with Alzheimer's Disease.

In a world grappling with the challenges of obesity, it's essential to recognize that the impact of excess weight extends beyond physical health. Obesity has reached alarming proportions globally. The World Health Organization (WHO) states that over 650 million adults were obese in 2016. This epidemic poses risks to cardiovascular health and raises concerns about its impact on neurological well-being. Emerging research sheds light on the intricate relationship between being overweight and neurological disorders. The brain and body communicate through a complex network of signals. Adipose tissue, commonly called fat, secretes hormones and inflammatory substances. When in excess, these can disrupt this communication, leading to a cascade of effects on the brain.

Obesity is associated with chronic low-grade inflammation. This inflammation doesn't only affect joints or organs but can also extend to the brain. Studies suggest that it may contribute to the development and progression of neurological disorders, including Alzheimer's Disease, multiple sclerosis, and Parkinson's Disease. Obesity-induced inflammation may exacerbate these conditions, potentially accelerating their progression.

Obesity often leads to insulin resistance, a condition where cells become less responsive to insulin. Hence, this contributes to diabetes but also affects cognitive function. Some studies suggest that insulin resistance may be a precursor to cognitive decline and conditions like Alzheimer's. Obesity also alters the balance of hormones in the body, including those responsible for mood regulation. This hormonal imbalance may increase the risk of mental health conditions, such as depression and anxiety, which are intertwined with neurological well-being. It is also a leading cause of sleep apnea, a condition characterized by interrupted breathing during sleep. Sleep apnea can lead to fragmented sleep patterns and reduced oxygen supply to the brain. Over time, this may contribute to cognitive impairment.

Understanding the intricate relationship between being overweight and neurological disorders is crucial to comprehensive health and well-being. By prioritizing weight management and adopting a balanced lifestyle, individuals can mitigate the risks associated with obesity and promote optimal brain function. As the saying goes, a healthy body leads to a healthy mind, and nurturing both aspects of our well-being is the key to a fulfilling life. Remember, small steps towards a healthier lifestyle can make a significant difference in the long run.

Parkinson’s disease is a progressive nervous system disorder that affects movement. This neurodegenerative disorder affects cells in a specific area of the brain. According to the Centers for Disease Control and Prevention (CDC), the associated symptoms make Parkinson’s disease the 14th cause of death in the United States.

Parkinson’s disease causes stiffness or slowing of movement. It can start so gradually that it is often missed in the early stages. Empowering you and your family with information can help your family get an earlier diagnosis. This article will cover what to expect regarding Parkinson’s disease causes, symptoms, stages, diagnosis, and treatments.

CausesThe cause of Parkinson’s Disease is mostly unknown. Those with Parkinson’s have low dopamine concentrations in their brain. However, some factors may increase the risk of Parkinson’s.

Experts think that a combination of factors such as genetic mutations, lifestyle factors, and environmental effects cause the degenerative disorder. It is more likely to occur in men over the age of 60 years old. Chemicals like Trichloroethylene (TCEs) and Polychlorinated Biphenyls (PCBs) also increase the risk for Parkinson’s disease.

SymptomsThe symptoms of Parkinson’s disease vary depending on how far the disease has progressed. Signs and symptoms are gradual and often start with a slight hand tremor. As the person with Parkinson’s advances along the spectrum, the signs and symptoms of the disorder worsen.

Parkinson’s signs and symptoms include:

• Tremor: Shaking often begins in your hand or fingers. Some rub their thumb and forefinger (pill-rolling tremor), while others experience hand shaking while at rest.
• Bradykinesia: As it progresses, Parkinson’s disease slows movement. This means taking shorter steps, dragging feet while walking, or struggling to stand from sitting. For some, routine tasks now seem complicated and time-consuming.
• Muscle stiffness: Any muscle in your body can become stiff, painful, and limit one’s range of motion.
• Impaired balance: Parkinson’s disease may only affect posture initially. However, eventually, balance problems follow.
• Loss of unconscious movements: Do you know the automatic actions you perform each day, like blinking, smiling, or swinging your arms while walking? Some with Parkinson’s experience a decreased ability to perform these.
• Speech: Your speech may become monotone or soft-spoken. Some hesitate before talking, speak more quickly, slowly, or even slur.
• Writing changes: Handwriting may become more complicated, while some find that it appears smaller than it used to.

As the disease progresses, the following may occur as a result of the above symptoms:

• Loss of bladder control
• Constipation
• Dementia
• Swallowing problems
• Depression
• Trouble sleeping
• Cognitive problems
• Fatigue
• Pain

Stages of Parkinson’s DiseaseThere are five stages of Parkinson’s disease.

• Stage 1: In this stage, the symptoms of Parkinson’s disease are mild, and diagnosis is unlikely.
• Stage 2: The symptoms are more pronounced, but balance is not impaired.
• Stage 3: While Parkinson’s disease is progressing, those remain independent in this stage.
• Stage 4: Patients performing daily tasks become difficult during this stage. Patients can still stand unassisted but often struggle to walk.
• Stage 5: This stage is the most advanced and requires around-the-clock care.

DiagnosisDiagnosing Parkinson’s disease may be challenging as the symptoms are mild at first. There is no specific test that diagnoses the illness. A neurologist, a doctor specializing in nervous system conditions, will evaluate your case. If it is early in the process, a follow-up appointment may confirm worsening symptoms.

The neurologist will ask questions like:

• How long ago did you first experience symptoms?
• Are there any associated symptoms?
• Are these symptoms constant, or do they come and go?
• Where do you experience the symptoms?
• What makes the symptoms better?
• What makes your symptoms worse?

They will base their diagnosis on your medical history, signs, symptoms, and a neurological and physical exam. The neuro exam will cover mental status, balance, motor function, and a sensory exam. This will cover items like:

• Pushing and pulling against the provider’s hands with arms and legs
• Moving from a seated position to standing and walking
• Standing with closed eyes and being pushed to one side or the other.
• Passive and active range of motion (ROM)
• Discussing person, place, and time (who you are, where you are, and when it is)
• Observation for speech and clarity
• Assessing sensation with dull needles, tuning forks, alcohol swab, and cotton bulls

Your healthcare provider may order other tests, such as blood work or imaging like an MRI. However, instead of diagnosing Parkinson’s, these tests rule out other conditions that may be causing these symptoms. In rare cases, you may receive a dopamine transporter scan (DaTscan) to support the suspicion of Parkinson’s.

Treatments
There are many medical and surgical options for treatments for Parkinson’s, but no cure. Some medications will manage problems with walking, tremors, and movement by increasing dopamine. Dopamine cannot directly enter your brain.
People with Parkinson’s disease have medication options:

• Carbidopa-levodopa is the most effective Parkinson’s disease medication. In fact, it is usually so effective that it is used as a diagnostic tool. If the symptoms improve significantly with the administration of this medication, it will confirm the diagnosis.
  • Levodopa is a natural chemical that your body converts to dopamine once it passes into your brain.
  • Carbidopa protects the levodopa from converting to dopamine before it passes into your brain and lessens side effects.
  • It can be taken orally, inhaled, or as a continuous gel through a feeding tube.
• Dopamine agonists are not as effective as levodopa but last longer.
• MAO B inhibitors prevent the breakdown of dopamine in the brain.
• Catechol O-methyltransferase (COMT) inhibitors slightly prolong the effect of levodopa by blocking dopamine breakdown.
• Anticholinergics were used for many years to control the tremor associated with Parkinson’s disease. However, the risks often outweigh the benefits with side effects like memory impairment, confusion, impaired urination, or constipation.
• Amantadine alone provides short-term relief of mild, early-stage Parkinson’s symptoms. It can also be given during more advanced stages to control involuntary movements caused by carbidopa-levodopa.
• A2A receptor antagonists are adenosine receptor antagonists that target areas in the brain that regulate the dopamine response to allow more dopamine to be released.
• Pimavanserin is a drug that treats delusions and hallucinations associated with Parkinson’s disease.

There is also a surgical procedure called deep brain stimulation, in which the surgeon implants electrodes into your brain that connect to a generator in your chest. The generator near your collarbone sends impulses to your brain to reduce symptoms. There are risks like infection, stroke, or bleeding.

Deep brain stimulation (DBS) is best for those with advanced Parkinson’s disease who have unstable responses to their drug regimen. However, it will not cure Parkinson’s nor stop it from advancing.

Questions to Ask Healthcare Providers about Parkinson’s Disease
Getting a diagnosis of Parkinson’s disease can seem overwhelming. For others, it may be helpful to finally understand the changes you’re experiencing. However, having a support network and working with your medical team is important. You should ask questions after the diagnosis, such as:

• What are my options for treatment?
• Are there side effects to these treatments?
• Are there any clinical trials or brand-new treatments?
• What other specialists should I see?
• What are the symptoms as Parkinson’s disease progresses?

Bottom line
While the cornerstone of Parkinson’s disease is worsening symptoms, there are ways to reduce them as the disease advances. The most crucial part of the treatment plan is a supportive network, coping tools, and safety measures. Coping tools include meditation, tai chi, yoga, or seeing a trusted therapist.
If balance becomes a problem, it is crucial to prepare the bathroom with grab bars and remove rugs. An occupational therapist can help with other strategies to promote safety.

Unfortunately, treatment cannot cure Parkinson’s disease, but you can manage the symptoms. Contact your healthcare provider or neurologist to start the conversation if you suspect that you or a loved one is symptomatic with Parkinson’s disease.

If you have questions about performing CPR for those with dementia, Pacific ACLS provides courses and a guide to first aid for people with dementia to give you a more in-depth look.

Works Cited

1. Centers for Disease Control. LCWK5: Deaths, Percent of Total Deaths, and Death Rates for the 15 Leading Causes of Death: United States and Each State, 2017. Updated December 31, 2018. Accessed October 17, 2022.
2. Parkinson’s Foundation. Environmental factors. Accessed October 17, 2022.
3. Mayo Clinic. Parkinson’s disease. Updated July 8, 2022. Accessed October 17, 2022.
4. Bastiaan RB, Okun MS, Klein C. Parkinson’s Disease. Lancet. 2021;397(10291):2284-2303.

​The attached PowerPoint is from Dr. Cokgor.  She did a wonderful presentation on “Cryptogenic Stroke” last Wednesday. 

Cryptogenic Stroke definition is basically - An ischemic stroke occurring without being able to discover the cause/source. Crypto (hidden or secret) Genic (producing or forming) Meaning that what produced the stroke is unknown.

Dr. Cokgor has several points that she wants to stress to us as nurses caring for the Cryptogenic Stroke Patient - Remember we do not know the cause for the stroke so……
​

1. Monitor their telemetry closely- watch for signs of atrial fib or any other arrhythmia
2. Look for signs of infection
3. Take a good history and ask the patient about drugs and alcohol (they might tell you and not the doctor)
4. Family history of strokes
5. Recent Miscarriages  https://academic.oup.com/humrep/article/20/6/1729/748934  This is an excerpt from the article - CONCLUSIONS: Both idiopathic and antiphospholipid syndrome (APS)-associated recurrent miscarriage were associated with a similar long-term risk of thrombosis.

View short videos regarding COVID-19 
​vimeo.com/showcase/6852479